Agaricus

IMMUNITY AND CLEANSING

Dual extraction | Full spectrum of active compounds | Organic cultivation

Agaricus (Agaricus blazei / Agaricus brasiliensis / Agaricus subrufescens), known as the “Brazilian mushroom” (in Japan: Himematsutake, in China: Ji Song Rong), is a functional mushroom valued primarily for its immunomodulatory effects and support for the body’s inflammatory balance. Rich in polysaccharides (especially β-glucans) and compounds with antioxidant potential, it is often chosen during periods of lowered immunity, overall strain, and when the goal is “cleansing” understood as supporting the body’s natural regenerative processes: the gut, the liver, and the immune system. Clinical studies have reported, among other outcomes, improved NK cell activity and quality of life in patients undergoing chemotherapy, as well as benefits in symptoms and fatigue in people with ulcerative colitis (in a study using an Agaricus-based extract).

INGREDIENTS

• Concentration: 15,000 mg in 30 ml
• Ingredients: Dual hydro-alcoholic extract 25%, organic Agaricus fruiting bodies, macerate

PRACTICAL USE

• Immune support and an “immune shield” - β-glucan polysaccharides may support the natural activity of immune cells; in a clinical study in patients undergoing chemotherapy, increased NK cell activity and improvements in selected aspects of well-being were observed.
• Gut “cleansing” and inflammatory balance - “cleansing” understood as easing the digestive system and supporting the intestinal barrier: in a randomized placebo-controlled trial (21 days), an Agaricus-based extract was associated with improvements in symptoms, fatigue, and selected quality-of-life domains in people with ulcerative colitis.
• Antioxidant support and a “reset” after overload - Agaricus bioactive compounds may support cellular protection against oxidative stress, which often accompanies chronic stress, sleep deprivation, and a pro-inflammatory diet.
• Recovery and comfort during periods of weakness - in clinical observations, Agaricus has been linked with improvements in quality-of-life elements (e.g., appetite, general weakness) in people undergoing treatment, which may be important during recovery.
• Liver and “cleansing” - with caution and awareness - Agaricus is sometimes described as supporting the liver from traditional and antioxidant perspectives; however, there are also reports of severe liver injury in some people using Agaricus extracts. Therefore, individuals with liver disease, those undergoing oncology treatment, or those taking multiple products should consult a clinician and consider monitoring liver enzymes.

Other potential benefits

• May support balance of the immune response (useful during infection seasons and recurrent colds).
• May support the “gut-immune axis” (indirectly influencing well-being and regeneration).
• Sometimes discussed in the context of lipid and metabolic support (data are mixed; best treated as part of lifestyle, not a “drug”).
• May support histamine balance and allergic responses (mainly preclinical/indirect data).
• May promote better adaptation to biological stress (fatigue, training overload, sleep deficit).
• In Asian traditions, sometimes linked with “strengthening” and nourishing the body after illness.
• May support healthy aging through antioxidant and anti-inflammatory activity (as support, not a promise of outcomes).

Characteristics according to Traditional Chinese Medicine (TCM)

• Temperature: neutral (“ping”)
• Taste: sweet
• Meridian affiliation: most often described as lungs, liver, kidneys (sometimes also the heart)

Expanded actions in TCM

1. Strengthens “Zheng Qi” and supports immunity
   • Traditionally associated with strengthening the body during weakness and reduced vitality.
2. Supports transformation and “clearing” of lingering factors
   • In culinary/herbal traditions, described as supporting respiratory harmony and “phlegm” as well as overall cleansing.
3. Supports the liver and kidneys
   • Traditionally linked with supporting “essence” and regeneration, especially after periods of weakness.
4. Supports the lungs
   • Traditionally used as part of the diet during periods of lowered immunity and respiratory weakness.
5. Supports returning to balance after stress
   • From an energetic perspective, it may help stabilize the body when “overload” affects digestion, sleep, and immunity.

DOSAGE

10 drops daily

• Consult a doctor or a TCM practitioner before use.
• Start with 2-4 drops, gradually increasing the dose during the first week.
• After one week of use, take a weekend break (Saturday-Sunday).
• After one month of continuous use, introduce a one-week break, then repeat the cycle.

ADDITIONAL INFORMATION

• Do not use in children under 3 years of age, pregnant women, or breastfeeding women.
• People with liver disease, a history of elevated liver enzymes, those undergoing oncology treatment, or those taking chronic medications should consult a doctor before use (there are reports of severe liver injury after Agaricus extracts in some patients).
• Store at room temperature, out of reach of small children.

Synergy of adaptogenic mushrooms - the most important duos and their effects

Chaga + Cordyceps (energy and physical endurance)

Synergy for power and performance: Pairing Chaga with Cordyceps is an ideal option for active people. Cordyceps supports energy production in mitochondria, improves oxygen capacity and circulation, which translates into better conditioning and training results. Chaga, in turn, helps reduce the feeling of fatigue, offers strong antioxidant activity, and supports faster tissue recovery.

Importantly, this duo also strengthens immunity - it provides a natural, caffeine-free boost of vitality while mobilizing the immune system. In other words, Chaga + Cordyceps offers clean energy and a solid protective barrier.

Chaga + Lion’s Mane (energy and mental clarity)

Synergy for vitality and focus: Combining Hericium (Lion’s Mane) with Chaga connects cognitive benefits with stable energy. Hericium is known for supporting memory, focus, and mood, while Chaga provides steady, clean energy and helps protect cells from oxidative stress.

The result is motivation and clear thinking without the nervousness typical of caffeine. This duo is often added to “mushroom coffee” to support body and mind in a balanced way.

Chaga + Reishi (vitality and stress reduction)

Synergy for immunity and balance: Chaga - a “king” of antioxidants - supports energy and the immune system, while Reishi - a valued “queen” of adaptogens - soothes the nervous system, helps manage stress, and supports healthy sleep.

Together, they offer an energy boost without a later “crash” and help ease tension. The blend provides antioxidants and polysaccharides, supporting both cellular protection and immunity.

Chaga + Shiitake (immune synergy)

Synergy for immunity: Chaga and Shiitake complement each other by supporting white blood cell activity, strengthening the body’s natural protective barrier, and helping reduce recurring infections.

This duo delivers beta-glucans and antioxidants, creating a true “immune shield” that helps protect cells from oxidative stress and pathogens.

Chaga + Coriolus (digestive health and immunity)

Synergy for gut and immunity: Coriolus provides PSP/PSK polysaccharides with prebiotic activity, while Chaga soothes mucosal irritation and supports healing. Together they support the microbiome and strengthen immunity under the principle “healthy gut - strong body”.

Chaga + Coriolus is a versatile combination - it supports the digestive tract, reduces inflammation, and strengthens immunity thanks to a high content of antioxidants and beta-glucans.

Cordyceps + Lion’s Mane (physical and mental energy)

Synergy for body and mind performance: Cordyceps supports ATP levels, endurance, and reduced fatigue, while Hericium supports NGF activity, benefiting memory and concentration.

Cordyceps + Hericium provide long-lasting energy during exertion and sharper thinking - ideal for people who work intensely both physically and mentally.

Cordyceps + Reishi (energy and stress-related fatigue reduction)

Synergy for vitality and calm: Cordyceps supports vitality and energy, while Reishi helps maintain nervous system balance, reduces tension, and supports immunity.

This combination helps you feel energized but not overstimulated - Cordyceps adds drive, and Reishi stabilizes the stress response, supporting long-term recovery and immune protection.

Cordyceps + Shiitake (endurance and recovery)

Synergy for endurance and renewal: Cordyceps improves oxygen utilization and supports muscle recovery, while Shiitake provides beta-glucans that support exercise-related immunity and valuable amino acids for tissue rebuilding.

As a result, Cordyceps + Shiitake provide a natural energy boost before training and faster recovery after exertion - without synthetic stimulants.

Cordyceps + Coriolus (vitality and immunity)

Synergy for protection and energy: Cordyceps boosts immune response and energy levels, while Coriolus - thanks to PSP/PSK - strongly modulates the immune system. Together they help protect against infections and support regeneration.

Cordyceps + Coriolus is a duo that supports both vitality and the body’s defense line, helping you recover faster after illness or intense exertion.

Lion’s Mane + Reishi (nervous system, mood, and sleep)

Nootropic + anti-stress synergy: Hericium supports neurogenesis, memory, and focus, while Reishi reduces stress, supports relaxation, and deepens sleep.

This combination supports mental clarity while also calming the system - ideal during periods of intense intellectual work or chronic stress.

Lion’s Mane + Shiitake (brain and immunity)

Synergy for cognition and a protective barrier: Hericium provides erinacines and hericenones that support neurons, while Shiitake provides lentinan that supports immune cells. The result is combined support for brain function and the immune system.

Hericium + Shiitake is a comprehensive blend for better memory, focus, and stronger immunity.

Lion’s Mane + Coriolus (brain, immunity, and gut)

Synergy for the gut-brain axis: Hericium supports digestive mucosa and nerve growth, while Coriolus supports the microbiome and helps reduce inflammation. Together they support cognition, immunity, and gut health.

Hericium + Coriolus is a dynamic duo supporting focus, mood, and digestive health, translating into better well-being and immunity.

Reishi + Shiitake (immune support and overall health)

Immunomodulating and health synergy: Reishi supports overall balance and calm, while Shiitake, rich in B vitamins and amino acids, supports the liver and cardiovascular system.

This duo strengthens immunity, protects against oxidative stress, and promotes healthy sleep - Reishi + Shiitake supports homeostasis and longevity.

Reishi + Coriolus (immunity and anti-inflammatory effect)

Synergy for the immune system: Reishi supports immune activity and stress adaptation, while Coriolus offers prebiotic and anti-inflammatory support. Together they support a faster return to balance.

Shiitake + Coriolus (double immune “boost”)

Synergy for immunity and recovery: Lentinan from Shiitake and PSK/PSP from Coriolus activate immune cells, providing double support against viruses and bacteria.

Shiitake + Coriolus is a natural “turbo booster” for immunity - it supports recovery, improves vitality, and may contribute to longevity thanks to antioxidant richness.

Agaricus + Coriolus (immunity and gut-regenerative cleansing)

Synergy “shield + restoration”: Agaricus strengthens the body’s defense line (immunomodulation) and supports inflammatory balance, while Coriolus acts strongly in the area of the gut and microbiome (PSP/PSK), translating into better immunity and “cleansing” understood as more efficient regeneration and renewal.

This is a particularly good duo during periods when immunity drops and the body needs both strengthening and calming support for the digestive system. Agaricus + Coriolus supports immunity, gut comfort, and regenerative processes - i.e., “cleansing” that works from within, without forcing the body.

Adaptogenic mushroom intake schedule according to the TCM body clock

Lion’s Mane (Hericium erinaceus)
Hours 7:00-9:00 - stomach, the best time to support digestion and the nervous system.
On an empty stomach or right after a light breakfast.
1-2 doses daily, at least 6 hours apart.

Chaga (Inonotus obliquus)
Hours 9:00-11:00 - spleen-pancreas, time for building Qi energy and immunity.
Best as a “morning tea”.
Once daily, in the morning.

Cordyceps (Cordyceps sinensis / militaris)
Hours 15:00-17:00 - urinary bladder, Yang energy is still high.
Supports endurance, energy, and kidneys.
1-2 times daily (morning and afternoon), not too late in the evening.

Reishi (Ganoderma lucidum)
Hours 21:00-23:00 - triple burner, preparation for sleep.
An ideal time for calming and regeneration.
Once daily, in the evening.

Amanita muscaria (fly agaric, microdosing)
Hours 5:00-7:00 - large intestine, cleansing and nervous system regulation.
In small morning doses as a nervous system reset.
Daily or every 2-3 days, depending on sensitivity.

General rules
Keep at least a 1-2 hour gap between different mushrooms.
Cordyceps and chaga can be combined in the morning or early afternoon.
Reishi always in the evening, preferably on its own.
Amanita only in the morning, never at night.
Most mushrooms can be taken daily; Amanita is better used in cycles every few days.

In-depth articles about individual Adaptogenic Mushrooms

Chaga

Reishi

Coriolus

Shiitake

Lion’s Mane

Cordyceps

SCIENTIFIC STUDIES ON AGARICUS

• Ahn W-S., Kim D-J. et al. “Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill… in gynecological cancer patients undergoing chemotherapy”. Int J Gynecol Cancer (2004)
  Aim: To evaluate the effect of oral supplementation with Agaricus blazei extract during chemotherapy on immune parameters and quality of life.
  Findings: Higher NK cell activity and improvement in selected chemotherapy-related complaints were observed (including appetite, general weakness, emotional stability).
• Therkelsen S.P. et al. “Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, … in Patients with Ulcerative Colitis…”. PLOS ONE (2016)
  Aim: A randomized placebo-controlled trial (21 days) evaluating an Agaricus-based extract for symptoms, fatigue, and quality of life in patients with ulcerative colitis.
  Findings: The intervention group showed improvements in symptoms, fatigue, and some HRQoL domains; no adverse effects were reported in this study.
• Mukai H. et al. “An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients”. Jpn J Clin Oncol (2006)
  Aim: Case reports of severe liver injury in oncology patients using Agaricus extract.
  Findings: The authors suggest a possible causal link and emphasize the need for caution and better-designed safety studies.

Agaricus supports immunity and overall balance, and treats “cleansing” as intelligent regeneration: gut support, immune support, and reducing inflammatory-oxidative overload.

This natural product is offered for its historical and ethnographic value and is supplied without any expressed or implied suitability for a particular purpose. It is simply a raw botanical specimen or a scientific sample. The information provided is intended solely for historical, scientific, and educational purposes and should not be interpreted as a recommendation for any specific use. The use and application of our product is at the customer’s own decision, responsibility, and risk.
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